Recurrent CA1 collateral axons in developing rat hippocampus.

نویسندگان

  • L Aniksztejn
  • M Demarque
  • Y Morozov
  • Y Ben-Ari
  • A Represa
چکیده

Rat perinatal (E20-P0) CA1 pyramidal neurons were either synaptically active or silent. We show here that, during this developmental period, active but not silent cells form recurrent axon-collaterals that invade the radiatum and the lacunosum moleculare strata. These recurrents were never observed in adult rats. We propose that these transient recurrent axons may participate in the activity-dependent modulation of the synaptogenesis

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Extrinsic and local glutamatergic inputs of the rat hippocampal CA1 area differentially innervate pyramidal cells and interneurons.

The two main glutamatergic pathways to the CA1 area, the Schaffer collateral/commissural input and the entorhinal fibers, as well as the local axons of CA1 pyramidal cells innervate both pyramidal cells and interneurons. To determine whether these inputs differ in their weights of activating GABAergic circuits, we have studied the relative proportion of pyramidal cells and interneurons among th...

متن کامل

The Effect of Noise Pollution Exposure during Pregnancy on Long Term Potentiation Induction in Pyramidal Neurons of Hippocampus CA1 area in Male Rat Offsprings

Background: It is believed that cognitive processing is easily disturbed by incompatible environmental stimulations. Many studies have shown that prenatal stress affects fetal brain development. The aim of this study was to evaluate the effect of noise pollution exposure during conception period on neural activity of hippocampus CA1 area in male rat offspring. Methods: Four groups of rats inclu...

متن کامل

Effects of Tamoxifen on Morphological and Ultrastructural Aspects of Developing Hippocampus of Rat

Background: Tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. The present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. Methods: After perfusion and fixation, the brains were removed and processed for light and e...

متن کامل

Action Potential Modulation in CA1 Pyramidal Neuron Axons Facilitates OLM Interneuron Activation in Recurrent Inhibitory Microcircuits of Rat Hippocampus

Oriens-lacunosum moleculare (O-LM) interneurons in the CA1 region of the hippocampus play a key role in feedback inhibition and in the control of network activity. However, how these cells are efficiently activated in the network remains unclear. To address this question, I performed recordings from CA1 pyramidal neuron axons, the presynaptic fibers that provide feedback innervation of these in...

متن کامل

Acute application of cholecystokinin and its effect on long-term potentiation induction at CA1 area of hippocampal formation in rat

Introduction: It has been demonstrated that cholecystokinin sulfated octapeptide (CCK-8s) can affect synaptic transmission in the hippocampus. Because one of the major experimental models to understand the events happening in synaptic plasticity is To Study the long-term potentiation (LTP), we decided to investigate the effect of concomitant administration of CCK-8s and tetanic stimulation of S...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Brain research

دوره 913 2  شماره 

صفحات  -

تاریخ انتشار 2001